The procedure for Auricularia auricula ethanol extracts was carried out as shown in Fig. Zhao, Department of Plant Sciences, China Agricultural University. auricula fruiting bodies were cultured in the Daxinganling region, Heilongjiang province, China, and it was authenticated by Dr. auricula to better understand their application in the prevention/treatment of cardiovascular disease using functional foods and nutraceuticals. The results of this study will advance knowledge of cardiovascular benefits of A. auricula ethanol extract (AAE), we investigated effects of AAE on serum and hepatic lipid profiles, HMG-CoA reductase activity, antioxidant status in addition to fecal excretion of neutral cholesterol and bile acids in ICR mice. Therefore, the present study was designed to investigate the hypocholesterolemic effects of A. However, there is no further investigation on the effect of these substances of A. auricula could inhibit lipid peroxidation and decrease liver damage in benzo(α)pyrene-treated mice (Chang et al. auricula ethanol extracts possessed the antioxidant and nitric oxide synthase activation properties. auricula contain not only polysaccharides, but also abundant alkaloid, thiamin, riboflavin, ascorbic acid, vitamin D 2 and minerals. auricula as the major ingredient with combination of other nutritional herbal foods (Luo et al. Most recently, some health-promoting diet formulae have been developed using A. 2006) and impact on lipid metabolism (Chen et al. auricula polysaccharide components (Aletor 1995), conformational change of A. auricula polysaccharides have similar biological activities as A. auricula has been focused on dietary fiber and polysaccharide components, mainly extracted from its fruiting body. 2004) and hypocholesterolemia (Cheung 1996). auricula was reported to have many biological activities, including anticoagulant activity (Yoon et al. auricula functional components, which prevented hypercholesterolemia contained polyphenolic compounds, in addition to polysaccharides.Īuricularia auricula is a precious macro-fungus and its fruiting bodies have been widely used in Chinese cuisine and are known for their pharmaceutical effects in Chinese traditional medicine. No apparent effects on serum triglycerides, low-density lipoprotein cholesterol, fecal excretion of neutral cholesterol and feeding efficiency were observed among all groups. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids. Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. The experimental group was fed cholesterol-enriched diet (CED) with oral administration of AAE (150 mg/kg/d b.w.) for 8-week, normal control group and CED control group received either a regular diet (RD) or CED along with oral administration of equal volume distilled water. Thirty-six mice were randomly assigned to three groups ( n = 12). AAE contained more than 16% (g/g) polyphenolic compounds, excluding other interfering factors such as polysaccharides, water-soluble fibre and protein. auricula (AAE) on hypercholesterolemia in ICR mice. The present study was designed to investigate the effects of ethanol extract of A. The cholesterol-lowering properties of Auricularia auricula are commonly attributed to the presence of polysaccharides based on previous research.
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